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KMID : 0960920020010020101
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 2 p.101 ~ p.106
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Dysfunction of Cerebral Blood Flow in Patients with Alzheimer’s Disease -Statistical Parametric Mapping analysis of Tc-99m ECD SPECT-
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Yang Dong-Won
Kim Beum-Saeng
Shon Young-Min
Park Jeong-Wook
Chung Yong-An
Sohn Hyung-Sun
Kim Sang-Yun
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Abstract
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Background and Objectives: Alzheimer’s disease (AD) is the most common cause of the dementia. Pathologic and functional changes and AD are known to be unevenly distributed in the brain. This study investigates changes of cerebral blood flow (CBF) in patients AD to determine brain regions with hypoperfusion that reflects progression of disease.
Methods: Tc-99m-ECD single photon emission computed tomography (SPECT) was performed to measure regional CBF and statistical parametric mapping (SPM) 99 soft ware was used for the automated and objective approach to analyze SPECT image date. Twenty-five patients with mild to moderate dementia who met NINCDS-ADRDA criteria for AD (male 11, female 14) and 17 age-matched normal control subjects were studied. The severity of AD was measured by clinical dementia rating (CDR) scale.
Results: SPM analysis of SPECT images revealed that CBF in the anterior cingulate gyrus, left superior parietal cortex, left medial frontal cortex, left inferior temporal cortex, right thalamus and left hippocampus was significantly decreased in AD patients compared with normal controls (corrected p<0.05). The reduction of CBF according to CDR was localized in the left hippocampus and inferior temporal cortex, right anterior and posterior cingulate cortex and right superior parietal cortex (uncorrected p<0.01).
Conclusions: Our data suggest that the cognitive dysfunction of AD is strongly related with functional abnormality in discrete brain areas. 99m-Tc ECD SPECT with SPM analysis could be used as a useful functional imaging tool in AD study.
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KEYWORD
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Alzheimer’s disease, Dementia, SPECT, Statistical parametric mapping
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